Helical chiral 2-aminopyridinium ions: a new class of hydrogen bond donor catalysts.
نویسندگان
چکیده
Helical chiral 2-aminopyridinium ions were designed as a significantly more acidic (active) dual hydrogen-bonding catalyst than commonly used (thio)urea-based systems. The helicene framework was specifically utilized to position an inherently chiral barrier on the hydrogen-bonding side of the catalyst. The catalyst reactivity and enantioselectivity were successfully demonstrated in additions of 4,7-dihydroindoles to nitroalkenes (0.5-2 mol % catalyst loadings, up to 98:2 er).
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 132 13 شماره
صفحات -
تاریخ انتشار 2010